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New Gene-Editing Technology Might Eliminate Huntington’s Disease Study Says

A new genetic editing tool able to give hope to people who have Huntington’s disease and progeria, which causes untimely aging, research says.

Published in Cell Research, the research says researchers at Salk Institute have created a new tool called SATI, that allows them to edit the mouse genome and target a big swath of genetic mutations and cell types.

Instead of replacing the difficulty genes entirely, the researchers used SATI to put an excellent copy of one of the genes into a particular part of the mouse’s DNA. The gene is later injected into the genome and corrects the mutation without replacing the whole gene.

Within the testing, scientists used SATI to correct the gene that’s liable for progeria in mice. Researchers mentioned that they noticed diminished aging in several organs, together with the skin and spleen, in addition to a 45 % increase within the lifespan of the mice with the disease.

Like progeria, Huntington’s disease is considered deadly, based on the HDSA (Huntington Disease Society of America). The genetic disorder “causes the gradual breakdown of nerve cells within the brain” and deteriorates a person’s physical and mental abilities throughout their prime working years. Presently, there isn’t any recognized cure.

While somewhat controversial in that it can cause genetic damage according to one study, CRISPR has been credited with few biological and scientific achievements. These include eliminating viruses in pigs that might be harmful to people, which could lay the foundations for pig-to-human organ transplants.

The gene-editing tool has additionally been used to repair, gene mutation caused by disease in human embryos, blocking the mutation from passing to future generations.

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